This study aims atidentifying the health conditions of Syrian refugee with disabilities  in urban area of Jordan and the situations of their and their families’ social participation. The subjects of the study were twelve participants of PWDs and their families in Jordan. Semi-structured interviews were conducted  and Qualitative Content Analysis Method was performed to assess the social participation of them. The study identified that the social participation of PWDs and their families in urban area could be often restricted, and that insufficient health care services, health literacy, disuse syndrome, and burdens of nursing care be correlated to the level of social participation of PWDs and their families. Therefore, It is essential that health professionals including occupational therapists provide knowledge and health services concerning the prevention of disuse syndrome and support for the empowerment of PWDs