This study explores the QOL among parents who have children with or without disabilities. A total of 147 parents were recruited for the study (71 had children with disabilities and 76 had children without disabilities) using convenience sampling. Results indicate that social relationships and environmental domains of QOL differed significantly between the two groups of parents, but there were no significant differences in physical health and psychological domains of QOL between the two groups. Moreover, Parental QOL and the disability levels of their children were positively correlated. Children with severe disabilities are more physically demanding of their parents, who might feel more stress when taking care of them. Parents’ physical and psychological well-being might directly affect their children. Results indicate the need for parental support when providing intervention to their children with disabilities.